Vaccine Fermenter (GMP) Microbial Bioreactors

Stainless Steel Bioreactor Fermenter (Customize)

20L

1:2/1:2.5

30L

1:2/1:2.5

50L

1:2/1:2.5

100L

1:2/1:2.5

150L

1:2/1:2.5

200L

1:2/1:2.5

300L

1:2/1:2.5

500L

1:2/1:2.5

1000L

1:2/1:2.5

2000L

1:2/1:2.5

5000L

1:2/1:2.5

10000L

1:2/1:2.5

20000L

1:2/1:2.5

50000L

1:2/1:2.5

60000L

1:2/1:2.5

Tank

Jacket tank, made by SS316 and SS304, tank design pressure 0.3Mpa, jacket design pressure 0.35Mpa, polishing 0.4-0.6um, ratio of diameter and height is 1:2.2-2.5

Stirring system

Mechanical drive on the top/bottom or Magnetic drive on the top, 3pcs height adjustable six-blade paddle,

Stir speed: 50~1000rpm/50-400rpm

Sterilization

Sterilize in place(SIP), auto control by program

Clean

Clean in place (CIP) by spray ball

Gas control

Control by rotor meter, air flow 1 vvm

Feeding

Automatically feeding by peristaltic pump

Anti-foam control

Automatically add antifoam by peristaltic pump

Temperature control

Auto-control,  electric heating range: water source add 5℃ to 70℃

PH control

PH 2.00-12.00±0.1, auto-control adding acid/base by peristaltic pump, pH sensor from Hamilton/Mettler, Switzerland.

Do control

0-150±3% displaying precision 0.1%, DO sensor from Hamilton/Mettler, Switzerland. DO coupling with agitation, oxygen.

Sampling

Sampling valve, can sterilization separately, manual

Harvest

Zero dead zone bottom valve(Gemu/Burket,Germany), can sterilization separately, manual/auto

Lid lift system

30L-500L have lid lift system, 700-1000L have human hole.

Pressure

Auto control, BD Germany pressure transmitter

Exhaust

Have condenser and filter before exhaust, control by diagram valve / Proportional control valve.

Weight system

Using le bottom fixation, thread concealed; Mettletoldo weighing sensor.

Control parameters

Stainelss steel bioreactor have 10 or 15 inch touch screen , Siemens PLC with control parameters (stirring, pH, DO, temperature, feeding, alarm, gas etc.), data analysis, data record, data output, language(RU/EN/CN) and other customized functions

Optional configuration

Remote control,

Mass flow meter(auto control gas), O2/N2/CO2, gas flow 2vvm, gas(CO2) exhaust analysis,

Turbidity(OD) sensor,

ORP sensor,

Live cell sensor(Biomass),

Siemens touch screen,

Double mechanical seal,

4-Valves-group for feeding,

Bottom valve auto discharge,

Batch culture, Seed transfer, etc.

Level sensor,

Printing,